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Article

Structural and kinetic characterization of the simplified SH3 domain FP1.

Protein science : a publication of the Protein Society - 1 Apr 2003

Yi Qian, Rajagopal Ponni, Klevit Rachel E, Baker David

Abstract excerpt

The simplified SH3 domain sequence, FP1, obtained in phage display selection experiments has an amino acid composition that is 95% Ile, Lys, Glu, Ala, Gly. Here we use NMR to investigate the tertiary structure of FP1. We find that the overall topology of FP1 resembles that of the src SH3 domain, the hydrogen-deuterium exchange and chemical shift perturbation profiles are similar to those of naturally occurring...

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Identifiers

PMID: 12649436
DOI: 10.1110/ps.0238603
PMCID: PMC2323857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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