Article
The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice.
Journal of neurochemistry - 1 Apr 2003
Dean Brian
Abstract excerpt
A large body of evidence shows that there is a change in the density of cortical serotonin2A receptors (5HT2AR) in post-mortem CNS from subjects with schizophrenia. Furthermore, some antipsychotic drugs have also been shown to cause a decrease in the density of 5HT2AR in the rat CNS. Thus, it appeared possible that changes in this receptor in human post-mortem CNS simply reflected an antipsychotic drug effect....
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