Purification, Cloning and Characterization of Variant LukE‐LukD with Strong Leukocidal Activity of Staphylococcal Bi‐Component Leukotoxin Family

doi:10.1111/j.1348-0421.2003.tb02789.x

Article

Purification, Cloning and Characterization of Variant LukE‐LukD with Strong Leukocidal Activity of Staphylococcal Bi‐Component Leukotoxin Family

1 Jan 2003

Abstract excerpt

Staphylococcus aureus produces bi-component leukotoxins composed of non-associated soluble proteins, S and F. Neither S nor F component alone is cytotoxic, but components together are active. These include Panton-Valentine leukocidin (PVL), gamma-hemolysin, LukE-LukD and others. Purification of leukotoxin from Staphylococcus aureus V8 strain (ATCC 27733) which does not have PVL genes, identified an F component...

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