Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity.

Journal of virology - 1 Apr 2003

Khan Mahfuz, Garcia-Barrio Minerva, Powell Michael D

Abstract excerpt

We have previously shown that virions with nef deleted can be restored to wild-type infectivity by treatment to induce natural endogenous reverse transcription (NERT). Since Nef and cyclophilin A (CyPA) appear to act in similar ways on postentry events, we determined whether NERT treatment would restore infectivity to virions depleted of CyPA. Our results show that the infectivity of virions depleted of CyPA by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid Proteins
Share to Cyclophilin A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclosporine

Share to Genes, nef

Share to Genes, Viral

Share to Immunosuppressive Agents

Share to Membrane Glycoproteins

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12634401
DOI: 10.1128/jvi.77.7.4431-4434.2003
PMCID: PMC150660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity.PMID 12634401Read ↗

Restoration of Wild-Type Infectivity to Human Immunodeficiency Virus Type 1 Strains Lacking nef by Intravirion Reverse TranscriptionSemantic proximity Read ↗

Nef enhances HIV-1 infectivity via association with the virus assembly complex.Semantic proximity Read ↗

Characterization of the Behavior of Functional Viral Genomes during the Early Steps of Human Immunodeficiency Virus Type 1 InfectionSemantic proximity Read ↗

trans-Complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity.Semantic proximity Read ↗

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.Semantic proximity Read ↗

Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.Semantic proximity Read ↗

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 ProteinSemantic proximity Read ↗

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.