Article
Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95).
International immunology - 1 Jul 1998
White C A, McCombe P A, Pender M P
Abstract excerpt
Morphological studies have shown that macrophages and microglia undergo apoptosis in the central nervous system (CNS) in acute experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. To assess the relative levels of macrophage and microglial apoptosis, and the molecular mechanisms invol...
Topics
- Animals
- Apoptosis
- Central Nervous System
- Encephalomyelitis, Autoimmune, Experimental
- Fas Ligand Protein
- Female
- Guinea Pigs
- Macrophages
- Membrane Glycoproteins
- Microglia
- Phenotype
- Rats