Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties.

doi:10.1128/jvi.77.7.3950-3961.2003

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Article

Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties.

Journal of virology - 1 Apr 2003

Lam Angela M I, Keeney David, Eckert Patrick Q, Frick David N

Abstract excerpt

The NS3 ATPase/helicase was isolated and characterized from three different infectious clones of hepatitis C virus (HCV). One helicase was from a genotype that normally responds to therapy (Hel-2a), and the other two were from more resistant genotypes, 1a (Hel-1a) and 1b (Hel-1b). Although the differences among these helicases are generally minor, all three enzymes have distinct properties. Hel-1a is less...

Topics

Adenosine Triphosphatases
Adenosine Triphosphate
Amino Acid Substitution
Base Sequence
DNA, Viral
Genetic Variation
Genotype
Hepacivirus
Hepatitis C
Humans
Hydrolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Kinetics

Molecular Sequence Data

RNA Helicases

Sequence Homology, Amino Acid

Substrate Specificity

Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12634355
DOI: 10.1128/jvi.77.7.3950-3961.2003
PMCID: PMC150621

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