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Article

Protein dynamics in a family of laboratory evolved thermophilic enzymes.

Journal of molecular biology - 28 Mar 2003

Wintrode Patrick L, Zhang Deqiang, Vaidehi Nagarajan, Arnold Frances H, Goddard William A

Abstract excerpt

Molecular dynamics simulations were employed to study how protein solution structure and dynamics are affected by adaptation to high temperature. Simulations were carried out on a para-nitrobenzyl esterase (484 residues) and two thermostable variants that were generated by laboratory evolution. Although these variants display much higher melting temperatures than wild-type (up to 18 degrees C higher) they are...

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PMID: 12634066
DOI: 10.1016/s0022-2836(03)00147-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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