Article
A mutation specific polymerase chain reaction for detecting hepatitis B virus genome mutations at nt551.
World journal of gastroenterology - 1 Mar 2003
Ma Chun-Ling, Fang De-Xing, Chen Hua-Biao, Li Fa-Qing, Jin Hui-Ying, Li Su-Qin, Tan Wei-Guo
Abstract excerpt
AIM: The hepatitis B surface antigen (HBsAg) is considered to be one of the best markers for the diagnosis of acute and chronic HBV infection. But in some patients, this antigen cannot be detected by routine serological assays despite the presence of virus. One of the most important explanations for the lack of detectable HBsAg is that mutations which occur within the "a" determinant of HBV S gene can alter...
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