Genome-wide etiology analysis of autoimmune hypothyroidism supports somatic mutations of at-risk DNA as the underlying cause.

doi:10.1210/endocr/bqag079

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Genome-wide etiology analysis of autoimmune hypothyroidism supports somatic mutations of at-risk DNA as the underlying cause.

Endocrinology - 3 Aug 2026

de Groen Piet C

Abstract excerpt

Autoimmune hypothyroidism (AIHT) is the most common autoimmune disease. Through an unidentified mechanism, the immune system attacks the thyroid gland, destroys thyroid follicular cells, and causes hypothyroidism. A new theory poses that all DNA is continuously damaged and, as a result, is exposed to somatic mutations at a constant rate. Based on this theory, several assumptions related to epidemiology and DNA...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Hashimoto Disease
Mutation
Thyroiditis, Autoimmune

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PMID: 42423170
DOI: 10.1210/endocr/bqag079
PMCID: PMC13507313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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