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Article

GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.

The Journal of biological chemistry - 3 Sept 2010

Sun Peng, Nallar Shreeram C, Raha Abhijit, Kalakonda Sudhakar, Velalar Chidambaram N, Reddy Sekhar P, Kalvakolanu Dhananjaya V

Abstract excerpt

GRIM-19 (Gene associated with Retinoid-IFN-induced Mortality-19) was originally isolated as a growth suppressor in a genome-wide knockdown screen with antisense libraries. Like classical tumor suppressors, mutations, and/or loss of GRIM-19 expression occur in primary human tumors; and it is inactivated by viral gene products. Our search for potential GRIM-19-binding proteins, using mass spectrometry, that permit...

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Source

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Identifiers

PMID: 20522552
DOI: 10.1074/jbc.M110.105767
PMCID: PMC2934621

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.PMID 20522552Read ↗

Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical CancersSemantic proximity Read ↗

Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.Semantic proximity Read ↗

Tumor-Suppressive Activity of the Cell Death Activator GRIM-19 on a Constitutively Active Signal Transducer and Activator of Transcription 3Semantic proximity Read ↗

Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in miceSemantic proximity Read ↗

Overexpression of GRIM-19 in Cancer Cells Suppresses STAT3-Mediated Signal Transduction and Cancer GrowthSemantic proximity Read ↗

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.Semantic proximity Read ↗

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GRIM-19 mutations fail to inhibit v-Src-induced oncogenesis.Semantic proximity Read ↗

Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues.Semantic proximity Read ↗

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A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomasSemantic proximity Read ↗

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