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Article

GRIM-19 mutations fail to inhibit v-Src-induced oncogenesis.

Oncogene - 12 Jun 2014

Kalakonda S, Nallar S C, Lindner D J, Sun P, Lorenz R R, Lamarre E, Reddy S P, Kalvakolanu D V

Abstract excerpt

The non-receptor tyrosine kinase Src is a major player in multiple physiological responses including growth, survival and differentiation. Overexpression and/or oncogenic mutation in the Src gene have been documented in human tumors. The v-Src protein is an oncogenic mutant of Src, which promotes cell survival, migration, invasion and division. GRIM-19 is an antioncogene isolated using a genome-wide knockdown...

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Identifiers

PMID: 23851499
DOI: 10.1038/onc.2013.271
PMCID: PMC3916943

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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