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Article

GRIM-19 in Health and Disease.

Advances in anatomic pathology - 1 Jan 2008

Máximo Valdemar, Lima Jorge, Soares Paula, Silva André, Bento Inês, Sobrinho-Simões Manuel

Abstract excerpt

GRIM-19, a gene associated with retinoid interferon-induced mortality, was originally identified as a critical regulatory protein for interferon-beta and retinoic acid-induced cell death. It was also demonstrated that GRIM-19 is involved in mitochondrial metabolism, as an integrant component of c...

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Source

Identifiers

PMID: 18156812
DOI: 10.1097/PAP.0b013e31815e5258

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18156812-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

GRIM-19 in Health and Disease.PMID 18156812Read ↗

Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in miceSemantic proximity Read ↗

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.Semantic proximity Read ↗

GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.Semantic proximity Read ↗

Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues.Semantic proximity Read ↗

Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.Semantic proximity Read ↗

GRIM-19 is essential for maintenance of mitochondrial membrane potential.Semantic proximity Read ↗

Tumor-Suppressive Activity of the Cell Death Activator GRIM-19 on a Constitutively Active Signal Transducer and Activator of Transcription 3Semantic proximity Read ↗

The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesisSemantic proximity Read ↗

Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis.Semantic proximity Read ↗

Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical CancersSemantic proximity Read ↗

A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomasSemantic proximity Read ↗

GRIM-19 Interacts with Nucleotide Oligomerization Domain 2 and Serves as Downstream Effector of Anti-bacterial Function in Intestinal Epithelial CellsSemantic proximity Read ↗

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