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Article

Inhibitory effect of troleandomycin on the metabolism of omeprazole is CYP2C19 genotype-dependent.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Feb 2003

He Nan, Huang Song-Lin, Zhu Rong-Hua, Tan Zhi-Rong, Liu Jie, Zhu Bing, Zhou Hong-Hao

Abstract excerpt

1. Eighteen healthy CYP2C19 genotyped male subjects were administered a 20-mg oral dose of omeprazole (OP) alone or received troleandomycin (TAO) 500 mg daily for 2 days before the dose of OP was administered. Blood samples were obtained and OP 5-hydroxyomeprazole (5-OH-OP) and OP sulfone in plasma were determined by reversed-phase HPLC. 2. The mean C(max), AUC and CL for OP in poor metabolizers (PMs) were...

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PMID: 12623762
DOI: 10.1080/0049825021000023996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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