Article
Probability of fixation of an advantageous mutant in a viral quasispecies.
Genetics - 1 Feb 2003
Wilke Claus O
Abstract excerpt
The probability that an advantageous mutant rises to fixation in a viral quasispecies is investigated in the framework of multitype branching processes. Whether fixation is possible depends on the overall growth rate of the quasispecies that will form if invasion is successful rather than on the individual fitness of the invading mutant. The exact fixation probability can be calculated only if the fitnesses of...
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