Article
Unbalanced expression of 11p15 imprinted genes in focal forms of congenital hyperinsulinism: association with a reduction to homozygosity of a mutation in ABCC8 or KCNJ11.
The American journal of pathology - 1 Jun 2001
Fournet J C, Mayaud C, de Lonlay P, Gross-Morand M S, Verkarre V, Castanet M, Devillers M, Rahier J, Brunelle F, Robert J J, Nihoul-Fékété C, Saudubray J M, Junien C
Abstract excerpt
Congenital hyperinsulinism (CHI), previously named persistent hyperinsulinemic hypoglycemia of infancy, is characterized by profound hypoglycemia because of excessive insulin secretion. CHI presents as two different morphological forms: a diffuse form with functional abnormality of islets throughout the pancreas and a focal form with focal islet cell adenomatous hyperplasia, which can be cured by partial...
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