Article
Role of molecular chaperones in inclusion body formation.
FEBS letters - 27 Feb 2003
Carrió M Mar, Villaverde Antonio
Abstract excerpt
Protein misfolding and aggregation are linked to several degenerative diseases and are responsible for the formation of bacterial inclusion bodies. Roles of molecular chaperones in promoting protein deposition have been speculated but not proven in vivo. We have investigated the involvement of individual chaperones in inclusion body formation by producing the misfolding-prone but partially soluble VP1LAC protein...
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