Article
Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2006
Chapman Eli, Farr George W, Usaite Renata, Furtak Krystyna, Fenton Wayne A, Chaudhuri Tapan K, Hondorp Elise R, Matthews Rowena G, Wolf Sharon G, Yates John R, Pypaert Marc, Horwich Arthur L
Abstract excerpt
In a newly isolated temperature-sensitive lethal Escherichia coli mutant affecting the chaperonin GroEL, we observed wholesale aggregation of newly translated proteins. After temperature shift, transcription, translation, and growth slowed over two to three generations, accompanied by filamentation and accretion (in approximately 2% of cells) of paracrystalline arrays containing mutant chaperonin complex. A...
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