Article
Studies of the paradoxical effect of caspofungin at high drug concentrations.
Diagnostic microbiology and infectious disease - 1 Mar 2005
Stevens David A, White Theodore C, Perlin David S, Selitrennikoff Claude P
Abstract excerpt
Turbid growth of some Candida albicans isolates occurs, paradoxically, in some high concentrations of caspofungin, above the minimum inhibitory concentration. We show that the resistant phenotype is first detectable after 24 h of drug exposure. Although other studies have suggested an association between some azole resistance mechanisms and caspofungin resistance, our studies with isolates susceptible and...
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