Article
Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies.
The Journal of investigative dermatology - 1 Mar 2003
Leyendeckers Heike, Tasanen Kaisa, Bruckner-Tuderman Leena, Zillikens Detlef, Sitaru Cassian, Schmitz Jürgen, Hunzelmann Nicolas
Abstract excerpt
Bullous pemphigoid is a subepidermal blistering disease characterized by the synthesis of autoantibodies against the 180 kDa and the 230 kDa bullous pemphigoid antigens. Whether autoimmunity is also reflected by the presence of circulating autoantigen-specific memory B cells is still a matter of debate. We used a new assay combining two-step immunomagnetic enrichment with multiparameter flow cytometry to detect...
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