Article
Correlation of Serum Levels of IgE Autoantibodies Against BP180 With Bullous Pemphigoid Disease Activity.
JAMA dermatology - 1 Jan 2017
van Beek Nina, Lüttmann Nadine, Huebner Franziska, Recke Andreas, Karl Ingolf, Schulze Franziska Sophie, Zillikens Detlef, Schmidt Enno
Abstract excerpt
Importance: Bullous pemphigoid (BP) is by far the most frequent autoimmune blistering disease. The presence of IgE autoantibodies against the transmembrane protein BP antigen 2 (BP180, type XVII collagen) has previously been reported in 22% to 100% of BP serum samples, and the pathogenic relevance of anti-BP180 IgE has been suggested in various experimental models and by the successful use of omalizumab in...
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