Activated ERK Signaling Is One of the Major Hub Signals Related to the Acquisition of Radiotherapy-Resistant MDA-MB-231 Breast Cancer Cells.

doi:10.3390/ijms22094940

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Activated ERK Signaling Is One of the Major Hub Signals Related to the Acquisition of Radiotherapy-Resistant MDA-MB-231 Breast Cancer Cells.

International journal of molecular sciences - 6 May 2021

Paramanantham Anjugam, Jung Eun Joo, Go Se-Il, Jeong Bae Kwon, Jung Jin-Myung, Hong Soon Chan, Kim Gon Sup, Lee Won Sup

Abstract excerpt

Breast cancer is one of the major causes of deaths due to cancer, especially in women. The crucial barrier for breast cancer treatment is resistance to radiation therapy, one of the important local regional therapies. We previously established and characterized radio-resistant MDA-MB-231 breast cancer cells (RT-R-MDA-MB-231 cells) that harbor a high expression of cancer stem cells (CSCs) and the EMT phenotype. In...

Topics

Apoptosis
Apoptosis Inducing Factor
Biomarkers, Tumor
Breast Neoplasms
Cell Line, Tumor
Cell Shape
Cell Survival
Clone Cells
Cyclophilin A
Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Humans

MAP Kinase Signaling System

Necroptosis

Neoplastic Stem Cells

Phenotype

Poly(ADP-ribose) Polymerases

Protein Interaction Maps

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Identifiers

PMID: 34066541
DOI: 10.3390/ijms22094940
PMCID: PMC8124562

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