Article
Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer.
Journal of molecular medicine (Berlin, Germany) - 1 Feb 2003
Yamada Yoshiji, Hamajima Nobuyuki, Kato Tomoyuki, Iwata Hiroji, Yamamura Yoshitaka, Shinoda Masayuki, Suyama Motokazu, Mitsudomi Tetsuya, Tajima Kazuo, Kusakabe Suzuno, Yoshida Hitoshi, Banno Yoshiko, Akao Yukihiro, Tanaka Masashi, Nozawa Yoshinori
Abstract excerpt
Phospholipase D plays an important role in transmembrane signaling in a variety of cell types and its activity is increased in certain cancers, suggesting that it also contributes to tumorigenesis. A C-->T transition at nucleotide 1814 of the human phospholipase D(2) gene, which results in a Thr-->Ile substitution at amino acid 577, was noted in the GenBank database. The relationship of this polymorphism to the...
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