Article
CARD15 gene mutations are not associated with ankylosing spondylitis.
Genes and immunity - 1 Jan 2003
van der Paardt M, Crusius J B A, de Koning M H M T, Murillo L S, van de Stadt R J, Dijkmans B A C, Peña A S, van der Horst-Bruinsma I E
Abstract excerpt
An insertion mutation at nucleotide 3020 (3020insC) and a missense mutation G2722C in the CARD15 gene on chromosome 16p have been reported to be associated with Crohn's disease (CD). The protein encoded by the CARD15 gene is expressed in peripheral monocytes and regulates apoptosis and NF-kappaB activation, factors which play an important role in inflammation. Since CD and ankylosing spondylitis (AS) are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.