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Article

Amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases.

Infection and immunity - 1 Mar 2003

Batten Margaret R, Senior Bernard W, Kilian Mogens, Woof Jenny M

Abstract excerpt

The amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by IgA1 proteases of different species of Streptococcus were investigated. Recombinant IgA1 antibodies were generated with point mutations at proline 227 and threonine 228, the residues lying on either side of the peptide bond at which all streptococcal IgA1 proteases cleave wild-type human IgA1. The amino acid...

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Identifiers

PMID: 12595464
DOI: 10.1128/IAI.71.3.1462-1469.2003
PMCID: PMC148859

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Source receipt: pubmed, retrieved 7 Sept 2026.

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