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Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae

1 Oct 1996

Abstract excerpt

The pneumococcus expresses a protease that hydrolyzes human immunoglobulin A1 (IgA1). A gene for IgA1 protease was identified from a plasmid library of pneumococcal DNA because of the effect of its overexpression on the colony morphology of Streptococcus pneumoniae. The deduced 1,964-amino-acid sequence is highly homologous to that of the IgA1 protease from Streptococcus sanguis. The similarity to the S. sanguis...

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Identifiers

PMID: 8926056
DOI: 10.1128/iai.64.10.3967-3974.1996

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