Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation.

American journal of obstetrics and gynecology - 1 Aug 2008

Lavie Ofer, Gruber Stephen B, Lejbkowicz Flavio, Dishon Sara, Rennert Gad

Abstract excerpt

OBJECTIVE: A founder mutation A636P in the MSH2 gene was found to be related to hereditary nonpolyposis colorectal cancer in Ashkenazi Jews. Although the incidence of colorectal cancer in carriers is relatively well established, the frequency of other tumors is less clear. STUDY DESIGN: We studied a consecutive series of 19 carrier families that were cared for by the Clalit Health Studies National Familial Cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Founder Effect

Share to Israel

Share to MutS Homolog 2 Protein

Share to Neoplasms, Second Primary

Share to Uterine Neoplasms

Source

Identifiers

PMID: 18674656
DOI: 10.1016/j.ajog.2008.02.018

Genes

MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation.PMID 18674656Read ↗

High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutation.Semantic proximity Read ↗

The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population.Semantic proximity Read ↗

The rate of the predominant Jewish mutations in the BRCA1, BRCA2, MSH2 and MSH6 genes in unselected Jewish endometrial cancer patients.Semantic proximity Read ↗

A636P testing in Ashkenazi Jews.Semantic proximity Read ↗

Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.Semantic proximity Read ↗

A636P is associated with early-onset colon cancer in Ashkenazi Jews.Semantic proximity Read ↗

An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC.Semantic proximity Read ↗

Colorectal and Endometrial Cancer Risk and Age at Diagnosis in BLMAsh Mutation Carriers.Semantic proximity Read ↗

Lynch Syndrome in high risk Ashkenazi Jews in Israel.Semantic proximity Read ↗

Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity.Semantic proximity Read ↗

Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations.Semantic proximity Read ↗

Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.