Article
Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob disease.
The New England journal of medicine - 20 Feb 2003
Zanusso Gianluigi, Ferrari Sergio, Cardone Franco, Zampieri Paolo, Gelati Matteo, Fiorini Michele, Farinazzo Alessia, Gardiman Marina, Cavallaro Tiziana, Bentivoglio Marina, Righetti Pier Giorgio, Pocchiari Maurizio, Rizzuto Nicola, Monaco Salvatore
Abstract excerpt
BACKGROUND: Olfactory cortexes and the olfactory tracts are involved in sporadic Creutzfeldt-Jakob disease. We examined peripheral regions of the olfactory sensory pathway, including the olfactory mucosa, to assess whether pathologic infectious prion protein (PrPSc) is deposited in the epithelium lining the nasal cavity. METHODS: We studied nine patients with neuropathologically confirmed sporadic...
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