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Article

Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing.

Scientific reports - 1 Jan 2012

Lim Ci Ji, Lee Sin Yi, Kenney Linda J, Yan Jie

Abstract excerpt

H-NS is an abundant nucleoid-associated protein in bacteria that globally silences genes, including horizontally-acquired genes related to pathogenesis. Although it has been shown that H-NS has multiple modes of DNA-binding, which mode is employed in gene silencing is still unclear. Here, we report that in H-NS mutants that are unable to silence genes, are unable to form a rigid H-NS nucleoprotein filament. These...

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Share to Bacterial Proteins
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Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22798986
DOI: 10.1038/srep00509
PMCID: PMC3396134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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