Article
Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma.
Journal of the National Cancer Institute - 19 Feb 2003
Wei Qingyi, Lee Jeffrey E, Gershenwald Jeffrey E, Ross Merrick I, Mansfield Paul F, Strom Sara S, Wang Li-E, Guo Zhaozheng, Qiao Yawei, Amos Christopher I, Spitz Margaret R, Duvic Madeleine
Abstract excerpt
BACKGROUND: The mechanism underlying the role of UV light exposure from sunlight in the etiology of cutaneous malignant melanoma (CMM) is unclear. Patients with xeroderma pigmentosum, a disease characterized by severe sensitivity to UV radiation and a defect in nucleotide excision repair, have a high incidence of CMM, which suggests that DNA repair capacity (DRC) plays a role in sunlight-induced CMM in the...
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