Article
Mutation of host DnaJ homolog inhibits brome mosaic virus negative-strand RNA synthesis.
Journal of virology - 1 Mar 2003
Tomita Yuriko, Mizuno Tomomitsu, Díez Juana, Naito Satoshi, Ahlquist Paul, Ishikawa Masayuki
Abstract excerpt
The replication of positive-strand RNA viruses involves not only viral proteins but also multiple cellular proteins and intracellular membranes. In both plant cells and the yeast Saccharomyces cerevisiae, brome mosaic virus (BMV), a member of the alphavirus-like superfamily, replicates its RNA in endoplasmic reticulum (ER)-associated complexes containing viral 1a and 2a proteins. Prior to negative-strand RNA...
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