Article
Identification and characterization of a host protein required for efficient template selection in viral RNA replication.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000
Díez J, Ishikawa M, Kaido M, Ahlquist P
Abstract excerpt
Biochemical studies suggest that positive-strand RNA virus replication involves host as well as viral functions. Brome mosaic virus (BMV) is a member of the alphavirus-like superfamily of animal and plant positive-strand RNA viruses. Yeast expressing the BMV RNA replication proteins 1a and 2a supports BMV RNA replication and mRNA synthesis. Using the ability of BMV to replicate in yeast, we show that efficient...
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