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Article

The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p.

American journal of human genetics - 1 Jan 1998

Li L, Drayna D, Hu D, Hayward A, Gahagan S, Pabst H, Cowan M J

Abstract excerpt

Severe combined immunodeficiency disease (SCID) consists of a group of heterogeneous genetic disorders. The most severe phenotype, T-B- SCID, is inherited as an autosomal recessive trait and is characterized by a profound deficiency of both T cell and B cell immunity. There is a uniquely high frequency of T-B- SCID among Athabascan-speaking Native Americans (A-SCID). To localize the A-SCID gene, we conducted a...

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PMID: 9443881
DOI: 10.1086/301688
PMCID: PMC1376812

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