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Article

B cell developmental requirement for the G alpha i2 gene.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2003

Dalwadi Harnisha, Wei Bo, Schrage Matthew, Spicher Karsten, Su Tom T, Birnbaumer Lutz, Rawlings David J, Braun Jonathan

Abstract excerpt

Null mutation of the Galphai2 trimeric G protein results in a discrete and profound mucosal disorder, including inflammatory bowel disease (IBD), attenuation of IL-10 expression, and immune function polarized to Th1 activity. Genetic and adoptive transfer experiments have established a role for B cells and IL-10 in mucosal immunologic homeostasis and IBD resistance. In this study, we addressed the hypothesis that...

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Share to B-Lymphocyte Subsets
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Injections, Intraperitoneal

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Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 12574334
DOI: 10.4049/jimmunol.170.4.1707

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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