Article
Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks.
The Journal of biological chemistry - 24 May 1996
Vander Molen M A, Rubin C T, McLeod K J, McCauley L K, Donahue H J
Abstract excerpt
To evaluate whether intercellular coupling via connexin43 gap junction channels modulates hormonal responsiveness of cells in contact, we have created osteoblastic cell lines deficient in connexin43. Osteoblastic ROS 17/2.8 cells were transfected with a plasmid containing an antisense cDNA construct to rat connexin43. Control transfection did not alter cell-to-cell coupling nor connexin43 mRNA or protein...
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