Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of optimal T-cell reactivity against the hepatitis C virus is associated with the development of fibrosis/cirrhosis during chronic hepatitis.

Human immunology - 1 Feb 2003

Sreenarasimhaiah Jayaprakash, Jaramillo Andrés, Crippin Jeffrey, Lisker-Melman Mauricio, Chapman William C, Mohanakumar T

Abstract excerpt

Chronic hepatitis C virus (HCV) infection develops in 85% of exposed individuals and 20% develop cirrhosis. However, the pathogenesis of this process is not well-understood. The objective of this study was to determine whether HCV-reactive T cells play a role in the process of development of cirrhosis during chronic HCV infection. We analyzed 21 human leukocyte antigen (HLA)-A2 patients with chronic HCV infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epitopes, T-Lymphocyte
Share to HLA-A2 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-5

Share to Mumps virus

Share to Th1 Cells

Share to Th2 Cells

Share to Viral Core Proteins

Share to Viral Matrix Proteins

Source

Identifiers

PMID: 12559624
DOI: 10.1016/s0198-8859(02)00781-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of optimal T-cell reactivity against the hepatitis C virus is associated with the development of fibrosis/cirrhosis during chronic hepatitis.PMID 12559624Read ↗

T cell responses in hepatitis C virus infection: historical overview and goals for future research.Semantic proximity Read ↗

Immune responses to hepatitis C and non-hepatitis C antigens in hepatitis C virus infected and HIV-1 coinfected patients.Semantic proximity Read ↗

Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responsesSemantic proximity Read ↗

Adaptive immune response during hepatitis C virus infection.Semantic proximity Read ↗

Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence.Semantic proximity Read ↗

CD8+T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction.Semantic proximity Read ↗

Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patientsSemantic proximity Read ↗

Innate and Adaptive Immune Responses in Chronic Hepatitis C Virus and Hepatitis B Virus Infection with High Viral LoadsSemantic proximity Read ↗

Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B.Semantic proximity Read ↗

According to Hepatitis C Virus (HCV) Infection Stage, Interleukin-7 Plus 4-1BB Triggering Alone or Combined with PD-1 Blockade Increases TRAF1low HCV-Specific CD8+ Cell Reactivity.Semantic proximity Read ↗

The immune response in chronic hepatitis B virus infection: the "core" of the problem?Semantic proximity Read ↗

Inflammation and repair in viral hepatitis C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.