Article
Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial.
AIDS (London, England) - 14 Feb 2003
Levy Yves, Durier Christine, Krzysiek Roman, Rabian Claire, Capitant Catherine, Lascaux Anne-Sophie, Michon Christophe, Oksenhendler Eric, Weiss Laurence, Gastaut Jean-Albert, Goujard Cécile, Rouzioux Christine, Maral Jean, Delfraissy Jean-François, Emilie Dominique, Aboulker Jean-Pierre
Abstract excerpt
BACKGROUND: Intermittent interleukin-2 (IL-2) therapy leads to a sustained increase of CD4 T cells in HIV-1-infected patients. METHODS: Symptom-free HIV-1-infected patients who were naive to all antiretroviral drugs (n = 68) and/or to protease inhibitors (n = 50) and had a CD4 cell count of 200-550 x 10(6) cells/l were randomly assigned to start lamivudine/stavudine/indinavir alone (controls) or combined from...
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