Increase of HIV-1 pro-viral DNA per million peripheral blood mononuclear cells in patients with advanced HIV disease (CD4<200 cells/mm3) receiving interleukin 2 combined with HAART versus HAART alone (ANRS-082 trial).

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Increase of HIV-1 pro-viral DNA per million peripheral blood mononuclear cells in patients with advanced HIV disease (CD4<200 cells/mm3) receiving interleukin 2 combined with HAART versus HAART alone (ANRS-082 trial).

Antiviral therapy - 1 Jun 2003

Delaugerre Constance, Gourlain Karine, Tubiana Roland, Carcelain Guislaine, Marcelin Anne-Geneviève, Chouquet Cécile, Mouroux Mireille, Duvivier Claudine, Autran Brigitte, Costagliola Dominique, Katlama Christine, Calvez Vincent

Abstract excerpt

OBJECTIVE: To assess the effect of interleukin (IL)-2 combined with highly active antiretroviral therapy (HAART) on HIV-1 pro-viral DNA quantification in HIV-1-infected patients with CD4<200/mm3. PATIENTS AND METHODS: Seventy patients with CD4<200 cells/mm3 and CV<1000 copies/ml were enrolled in a 6-month randomized controlled study to evaluate the subcutaneous injection of IL-2 in addition to HAART versus HAART...

Topics

Anti-HIV Agents
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
DNA, Viral
Drug Resistance, Viral
Drug Therapy, Combination
Female
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV-1

Humans

Interleukin-2

Leukocytes, Mononuclear

Male

Mutation

Source

Open in PubMed

Identifiers

PMID: 12924540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Increase of HIV-1 pro-viral DNA per million peripheral blood mononuclear cells in patients with advanced HIV disease (CD4<200 cells/mm3) receiving interleukin 2 combined with HAART versus HAART alone (ANRS-082 trial).PMID 12924540Read ↗

Immunological changes in peripheral blood and in lymphoid tissue after treatment of HIV-infected subjects with highly active anti-retroviral therapy (HAART) or HAART + IL-2.Semantic proximity Read ↗

Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial.Semantic proximity Read ↗

Pilot study of a combination of highly active antiretroviral therapy and cytokines to induce HIV-1 remission.Semantic proximity Read ↗

Rapid Turnover of 2-LTR HIV-1 DNA during Early Stage of Highly Active Antiretroviral TherapySemantic proximity Read ↗

Efficacy of low-dose intermittent subcutaneous interleukin (IL)--2 in antiviral drug--experienced human immunodeficiency virus--infected persons with detectable virus load: a controlled study of 3 il-2 regimens with antiviral drug therapy.Semantic proximity Read ↗

Interleukin-2 inhibits HIV-1 replication in some human T cell lymphotrophic virus-1-infected cell lines via the induction and incorporation of APOBEC3G into the virion.Semantic proximity Read ↗

Direct Evidence of Lower Viral Replication Rates In Vivo in Human Immunodeficiency Virus Type 2 (HIV-2) Infection than in HIV-1 InfectionSemantic proximity Read ↗

Cell-Associated Viral Burden Provides Evidence of Ongoing Viral Replication in Aviremic HIV-2-Infected PatientsSemantic proximity Read ↗

Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infectionSemantic proximity Read ↗

HIV Type 2 Proviral Load Measured by Quantitative Polymerase Chain Reaction Correlates with CD4 <sup>+</sup> Lymphopenia in HIV Type 2-Infected IndividualsSemantic proximity Read ↗

HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.