Contribution of Germline Mutations in<i>BRCA2</i>,<i>P16^<i>INK4A</i></i>,<i>P14^<i>ARF</i></i>and<i>P15</i>to Uveal Melanoma

Abstract excerpt

PURPOSE: Reports suggest that a subset of uveal melanoma is familial. The association of uveal melanoma with breast and ovarian cancer and the increased risk in BRCA2-linked families implicates germline BRCA2 mutations as the cause of a subset of uveal melanomas. Similarly, the association between cutaneous and uveal melanomas in some families, coupled with the high frequency of somatic deletions of the INK4A-ARF...

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