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Article

Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells.

The EMBO journal - 3 Feb 2003

Cohen Ehud, Taraboulos Albert

Abstract excerpt

Prion diseases are infectious, sporadic and inherited fatal neurodegenerations that are propagated by an abnormal refolding of the cellular prion protein PrP(C). Which chaperones assist the normal folding of PrP(C) is unknown. The linkage of familial Gerstmann- Sträussler-Scheinker (GSS) syndrome with proline substitutions in PrP raised the prospect that peptidylprolyl cis-trans isomerases (PPIases) may play a...

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Source

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Identifiers

PMID: 12554642
DOI: 10.1093/emboj/cdg045
PMCID: PMC140730

Genes

GSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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