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Article

Identification of small molecule compounds that selectively inhibit varicella-zoster virus replication.

Journal of virology - 1 Feb 2003

Visalli Robert J, Fairhurst Jeanette, Srinivas Shamala, Hu William, Feld Boris, DiGrandi Martin, Curran Kevin, Ross Adma, Bloom Jonathan D, van Zeijl Marja, Jones Thomas R, O'Connell John, Cohen Jeffrey I

Abstract excerpt

A series of nonnucleoside, N-alpha-methylbenzyl-N'-arylthiourea analogs were identified which demonstrated selective activity against varicella-zoster virus (VZV) but were inactive against other human herpesviruses, including herpes simplex virus. Representative compounds had potent activity against VZV early-passage clinical isolates and an acyclovir-resistant isolate. Resistant viruses generated against one...

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Identifiers

PMID: 12551972
DOI: 10.1128/jvi.77.4.2349-2358.2003
PMCID: PMC141108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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