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Studies of Infection and Experimental Reactivation by Recombinant VZV with Mutations in Virally-Encoded Small Non-Coding RNA.

Viruses - 10 May 2022

Bisht Punam, Das Biswajit, Borodianskiy-Shteinberg Tatiana, Kinchington Paul R, Goldstein Ronald S

Abstract excerpt

Locked-nucleotide analog antagonists (LNAA) to four varicella zoster virus small non-coding RNA (VZVsncRNA 10-13) derived from the mRNA of the open reading frame (ORF) 61 gene individually reduce VZV replication in epithelial cells and fibroblasts. To study the potential roles VZVsncRNA 10-13 have in neuronal infection we generated two recombinant VZV; one in which 8 nucleotides were changed in VZVsncRNA10...

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PMID: 35632756
DOI: 10.3390/v14051015
PMCID: PMC9144856

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