Article
Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin.
BMC genomics - 31 Aug 2016
Zhao Bi, Xue Bin
Abstract excerpt
BACKGROUND: Beta-catenin has two major functions: coordinating cell-cell adhesion by interacting with cadherin in cadherin junction formation pathway; and regulating gene expression through Wnt signaling pathway. Accomplishing these two functions requires synergistic action of various sequential regions of the same beta-Catenin molecule, including the N-terminal tail, the middle armadillo domain, and the...
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