Article
Oxidative capacity correlates with muscle mutation load in mitochondrial myopathy.
Annals of neurology - 1 Jul 2003
Jeppesen Tina D, Schwartz Marianne, Olsen David B, Vissing John
Abstract excerpt
The purpose of this study was to investigate the correlation between the level of mutated mitochondrial DNA in muscle and oxidative capacity in 24 patients with mitochondrial myopathy (MM). Maximal oxygen uptake (VO(2max)), workload (W(max)), and venous plasma lactate levels were measured during an incremental cycle test to exhaustion in 17 patients with point mutations of mtDNA and in seven with single,...
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