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Article

High‐throughput tissue microarray analysis of G1‐cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1

17 Jan 2003

Abstract excerpt

Deregulation of G1-cyclins (CCN) plays a key role in the pathogenesis of many human malignancies, including non-Hodgkin's lymphomas (NHLs). In contrast to NHL, little is known about phenotypic and genotypic changes in the regulation of the cell cycle in classical Hodgkin's lymphoma (cHL). To facilitate analysis of aberrant gene expression in cHL, a lymphoma tissue microarray (TMA) containing 752 cores of 330...

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PMID: 12533833
DOI: 10.1002/path.1279

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