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Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression

1 Apr 2009

Abstract excerpt

Low molecular weight (LMW) isoforms of cyclin E are post-translationally generated in breast cancer cells and are associated with aggressive disease and poor prognosis. In this study, the specificity of LMW cyclin E to cancer cells was determined by measuring cyclin E expression in tumor and non-tumor tissue from 340 breast cancer patients. Our results reveal the LMW isoforms were detected significantly more...

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Identifiers

PMID: 19305161
DOI: 10.4161/cc.8.7.8119

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