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Article

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?

The Journal of pathology - 1 Feb 2003

Sieber Oliver, Lipton Lara, Heinimann Karl, Tomlinson Ian

Abstract excerpt

The APC I1307K allele is believed to predispose to multiple colorectal tumours because the change at the nucleotide level-A(3)TA(4) to A(8)-creates a hypermutable site. Slippage of the A(8) tract undoubtedly occurs more often than expected in the tumours of I1307K carriers, but many of these tumours do not harbour changes at this site. Outside the A(8) tract, the tumours of I1307K carriers appear to harbour fewer...

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PMID: 12533824
DOI: 10.1002/path.1272

Genes

APC

Variants

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Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?PMID 12533824Read ↗

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