Article
Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis.
American journal of respiratory and critical care medicine - 1 Apr 2003
López-Maderuelo Dolores, Arnalich Francisco, Serantes Rocio, González Alicia, Codoceo Rosa, Madero Rosario, Vázquez Juan J, Montiel Carmen
Abstract excerpt
Several genes coding for different cytokines may affect host susceptibility to tuberculosis. This study investigates the relationship of the single base change polymorphic variants identified in the first intron of interferon-gamma (+874 T/A) and in the promoter region of interleukin-10 gene (-1,082 G/A), with cytokine production by peripheral blood mononuclear cells and tuberculosis susceptibility. We studied a...
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