Article
The human MC2-R gene expression: different aspects of its control.
Endocrine research - 1 Nov 2002
Blondet A, Doghman M, Penhoat A, Durand P, Bégeot M, Naville D
Abstract excerpt
Expression of the adrenocorticotropin receptor (MC2-R) is restricted to adrenocortical cells and is up-regulated by both adrenocorticotropin and angiotensin II through the activation of protein kinase A and protein kinase C pathways, respectively. After cloning of the promoter region of the human MC2-R gene (hMC2-R), we have shown that cyclic AMP-induced regulation of transcriptional activity of the gene is...
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