Article
Functional expression of the human ACTH receptor gene.
Endocrine research - 1 Nov 2000
Penhoat A, Naville D, El Mourabit H, Buronfosse A, Durand P, Bégeot M
Abstract excerpt
The ACTH receptor is the type 2 (MC2R) among the melanocortin receptor family and is expressed almost exclusively in the adrenal cortex. The human MC2R (hMC2R) was very difficult to express in heterologous cell lines. We have succeeded in transient and stable expression of hMC2R using the M3 melanoma cells. Moreover, we have found that the expressed hMC2R in M3 cells showed similar ACTH binding affinity and...
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