Article
SF-1 and the transcriptional regulation of the human ACTH receptor gene.
Endocrine research - 1 Jan 2000
Naville D, Penhoat A, Marchal R, Durand P, Bégeot M
Abstract excerpt
The adrenocorticotropin receptor or ACTH-R which is the type 2 among the melanocortin receptor family is almost exclusively expressed in the adrenal cortex, reflecting a high degree of tissue specificity. In human cultured adrenocortical cells, we have previously reported that ACTH in contrast to most of the peptide hormones, is able to up-regulate the number of its own receptors through an increase of the...
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